Acid tert-butyl ester, the chemical formula is C12H22N2O3, is an organic compound. It is a solid, white crystal at room temperature, soluble in organic solvents such as ethanol and dichloromethane.
The acid tert-butyl ester is a compound that protects the amino group and is widely used in organic synthesis. One of its main uses is to protect amino groups in the preparation of pharmaceutical intermediates in the synthesis of new drugs and bioactive molecules. Because of its high stability, it can prevent non-specific chemical reactions from attacking amino groups, so it is an important intermediate in organic synthesis.
The method of preparing a tert-butyl ester is relatively simple. A common method is the reaction of azetidinomethylamine with Boc-anhydride to produce a tert-butyl ester. The reaction is carried out under basic conditions, usually using potassium carbonate or triethylamine as a base catalyst.
When using acid tert-butyl ester, you need to pay attention to its safety. It is a flammable solid that is prone to burn when exposed to open flames. Care should be taken to prevent inhalation of dust or vapors and to avoid contact with skin, eyes or clothing. Wear appropriate personal protective equipment such as chemical protective gloves and goggles when used. At the same time, it should be stored in a closed container, away from fire and oxidizing agents. In the event of an accident, appropriate emergency measures should be taken immediately and the help of a professional doctor should be sought.